Tucson. In 1930, a building permit was issued to construct what would become the Arizona Inn, a nationally recognized resort officially opening in December 1930 amidst the perils of the Great Depression.

Having entered politics a few years earlier when in 1928 she was elected a Democratic National Committeewoman, Isabella would in 1932 officially nominate Franklin D. Roosevelt for President at the Democratic National Convention. In 1933, during a special election, Isabella was elected to the U.S.